Organ-on-Chip and Organoids Technology for Drug Development

Objectifs du cours

• Vision to create advanced tissue models in drug development to perform a reverse translation from human to in vitro to predict from in vitro to human including personalized healthcare

• Overview of cell source and production of three-dimensional organotypic tissue culture such as organoids

• Microengineering of organ-on-chip systems: design, materials selection, microfabrication techniques, actuators/sensors, and interface

• Merging organ-on-chip and organoids technology to develop the next generation of organ-on-chip platforms for modelling disease pathogenesis

• Challenges for the industrialization of organ-on-chip systems

• Perspectives of multiorgan- and body-on-chip platforms to mimic human physiology as well as organism-on-chip

Public cible

Scientists, managers and decision makers from the pharma and biotech industry, researchers, engineers, and clinicians. People developing complex in vitro models or involved in the alternatives to animal testing.

Contenu

Need for alternative testing methods and opportunities for organ-on-chip systems: Biological models - Requirements for in vitro alternatives to animal testing - Personalized medicine

Cell source and three-dimensional multicellular in vitro tissue constructs: Cell types - Basics of cell culture - Organoid technology - Production, sorting, assembling, maturation, analysis

Organ-on-chip engineering: Design - Materials - Fabrication process - Fluid control - Stimulation and sensing

Organ-on-chip platforms recapitulating (patho)physiological responses: Lung-on-chip - Brain-on-chip - Liver-on-chip

Industrialization of organ-on-chip systems: Biology needs to be correct - Parallelization for high throughput - Automation for standardization

Organ-organ interactions: Body-on-chip concepts - Elegans-on-chip

Enseignant(s)

Gilles Weder holds a BSc in general biology, MSc in medical biology and PhD in cell biology. He is Team Leader Life Microtechnologies at CSEM Neuchâtel. He is interested in the development of innovative technologies using life interacting microsystems. He has a particular focus on complex in vitro models, organ-on-chip systems and organoids for drug testing and regenerative medicine applications. He is the coordinator of the EU-funded ORGANTRANS project and a high school teacher.

Date et Lieu (jj.mm.aaaa) 07.11.2023 | Neuch√Ętel, FSRM
Coût (EARLY BIRD) CHF 690.00
Coût CHF 890.00
Langue English
Inscription Deux semaines avant le cours
Organisation FSRM, Fondation suisse pour la recherche en microtechnique
Informations et inscription Gilles Delachaux, FSRM, e-mail: fsrm@fsrm.ch