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Using organ-on-a-chip technology to reduce animal testing
Objectifs du cours
To provide a state of the art review of current methods for in-vitro testing of safety and efficacy of chemicals (including drugs) as well as studying disease and more general medical research.
To provide a detailed description of the latest advances in the technologies used for cell culture and the monitoring of cell function.
To describe the barriers and drivers to change, particularly the reduction and replacement of animal testing ( ethical, scientific, economic ).
To describe the technical challenges in creating and maintaining cell culture in a way that mimics the human environment (ie physiologically relevant models).
To analyse the specific challenges of scaling in-vitro models to the micro-scale needed to create the organ or human-on-a-chip.
Scientists and Managers working in the pharmaceutical, nutraceuticals, cosmetics, tobacco or chemical industry where animal testing has been or still is used to test product safety and efficacy.
Researchers working in academia or industry developing new methods of in-vitro testing.
Applications and markets where animal testing is used.
Advantages and disadvantages of using animals compared to in-vitro or in-silico methods.
The technologies used for in-vitro testing
- Sources of cells
- Culture media
- Cell culture chambers
- Scaffolds and other 3D approaches
- Assays and analysis methods
The evolution of lab-on-a-chip, organ-on-a-chip and human-on-a-chip technologies
Processes for gaining regulatory approval for new methods of testing safety and efficacy
The economics of testing using animals, in-vitro or in-silico models
Sources of research funding for the development of alternative methods
Companies and organisations developing alternative methods
Sources of further information (conferences, workshophs, web sites)
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